Preclinical Mouse Models for Checkpoint Mechanistic Studies and Immunotherapy Evaluations

Introduction to Mouse Models for Human Cancers

Mice and humans are deemed to have diverged from each other ~87 million years ago, sharing not only considerable similarities between the two species that make mouse models of human disease feasible, but also numerous significant differences, including distinctions in immune systems and drug metabolism.

Mouse models are designed to capture the complexities of human cancers, offering preclinical opportunities for investigating diversified mechanisms that provide theory evidence for therapeutic development. As the investigation of cancers has gone deeper and deeper, researchers have also become more capable of designing mouse models that better represent cancer patients. To date, mouse models of human cancer have markedly contributed to accumulating knowledge of the dual role of both the immune system in tumor progression and oncogenesis. The relationship between tumor cells and the host immunity system was revealed first in mouse models of cancer, subsequently leading to the boom of studies and applications of immune checkpoint therapy.

Fig. 1 Mouse cancer modeling.¹

Preclinical Mouse Models for Checkpoint Mechanistic Studies and Immunotherapy Evaluations

Here, Creative Biolabs briefly introduces the characteristic and promising use of mouse models of human cancer for immune checkpoint studies to our clients, with a focus on the "humanized" mice for preclinical and personalized assessment of checkpoint drugs.

Our discussion is mainly based on the following four sections:

• Spontaneous and Induced Mouse Tumor Models
• Genetically Engineered Mouse Models (GEMM)
• Tumor Cell Transplant Models
• Human Immune System Mouse Models

Services at Creative Biolabs

Preclinical mouse models are an essential tool for navigating the mechanisms and evaluating the efficacy of immune checkpoint therapy. Based on abundant experience and advanced technology platforms, Creative Biolabs provides professional services related to immune checkpoint to assist you in research, including but not limited to:

• Custom Immune Checkpoint Protein Development
• Antibody Development for Immune Checkpoints
• Immune Checkpoint Targeted Peptide Development
• Immune Checkpoint Targeted Small Molecule Drug Development
• Biomarker Development for Immune Checkpoint Inhibitor (ICI)
• Immune Checkpoint Assays
• Preclinical Research for Immune Checkpoint Targeting Drugs

If you are interested in any one of our services, please feel free to contact us for more details.

Reference

1. Day, et al. "Preclinical mouse cancer models: a maze of opportunities and challenges." Cell 163.1 (2015): 39-53.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic, or any in vivo human use.