CD27, also known as TNFRSF7, is a member of the tumor necrosis factor receptor (TNFR) superfamily. It has been served as the promising co-stimulatory immune checkpoint molecule for anti-cancer drug discovery. CD27 is expressed on naïve and activated T cells, NK cells, and activated B cells.
CD70, also known as CD27L or TNFSF7, is a typical representative of the tumor necrosis factor (TNF) ligand superfamily (TNFSF). CD70 is expressed as a single spanning transmembrane protein with an extracellular domain. CD70 is expressed by T cells, B-cells, lymphomas, and a considerable fraction of solid tumors. CD70 strongly stimulates the expression of CD27 and also CD27-associated signaling pathways. As a ligand-receptor pair of the TNF ligand and receptor family, CD70 and CD27 play essential roles in T-cell costimulation.
The CD27 and CD70 pathway presents a series of functions to regulate the T cell response in different stages. The mechanisms of actions including:
As the promising target for cancer treatment, a series of drugs targeting the CD27 and CD70 pathway have been discovered.
Fig.1 Mechanisms of action of the CD27/CD70 co-stimulatory system in the regulation of the T-cell response. (Van, 2015)
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