Immune Checkpoint Antibody Development

With our world-leading technology platforms and professional experts at antibody development, Creative Biolabs has perfected our technical pipelines in immune checkpoint antibody development. Our comprehensive service portfolio includes polyclonal antibody discovery and development, monoclonal antibody (mAb) discovery and development, antibody fragment discovery and development, antibody characterization, antibody engineering and optimization, antibody production, and manufacture. We will share our knowledge and passion for immune checkpoint antibody development to facilitate our customers' research and project development.

Immune Checkpoint Antibody for Cancer Therapy

Tumor cells can evade destruction by the immune system by triggering immune checkpoints, including but not limited to PD-1, CTLA-4, LAG-3, TIM-3, TIGIT, and BTLA, which are expressed on T-cells and whose engagement inhibits T-lymphocyte function. Immune checkpoints act as gatekeepers of immune responses. These receptors often use mono-tyrosine signaling motifs, such as immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM), to deliver inhibitory signals. As surface molecules, their activity can be easily inhibited by blocking antibodies to inhibit the engagement of the checkpoint molecules, thereby reinvigorating the antitumor immune responses. The most successful immune checkpoint blockade therapy is anti-PD-1/PD-L1 therapy that has been approved to treat a wide variety of cancer types. Immune checkpoint blockade therapy often leads to a more durable response than chemo or targeted therapies, perhaps reflecting the memory feature of the immune system.

Immune Checkpoint Antibody Development Service Portfolio at Creative Biolabs

  • Custom Immune Checkpoint Polyclonal Antibody Discovery and Development
  • The polyclonal antibody is still an essential research activity. As a leading custom service provider in the antibody field, Creative Biolabs offers an enormous variety of immune checkpoint antibody development services for different hosts, such as rabbit, goat, chicken, mouse, rat, bovine, monkey, ferret, hamster, camel, guinea pig, canine, and many other animals.

  • Custom Immune Checkpoint Monoclonal Antibody Discovery and Development
  • Diverse cutting-edge technologies, such as hybridoma technology, phage display technology, and antigen-specific single B cells sorting technology, have been employed for immune checkpoint mAb discovery and development. Various species are available, including human, mouse, rat, monkey, hamster, rabbit, bovine, canine, chicken, guinea, goat, sheep, pig, ferret, and horse. With Ph.D. level scientists and over a decade of experience in antibody development, Creative Biolabs is dedicated to serving every unique need of our clients in immune checkpoint mAb development projects by providing custom services.

  • Custom Immune Checkpoint Antibody Fragment Discovery and Development
  • Creative Biolabs is pleased to share our cutting-edge technology and extensive expertise in immune checkpoint antibody fragment discovery and development. A wide range of formats is available, including Fab, scFv, CARs, bispecific antibodies, etc. We offer high-quality custom services to meet even the most specific requirements.

  • Characterization of Immune Checkpoint Antibody
  • Well-characterized and validated antibodies are essential for antibody research and biopharmaceutical development. Creative Biolabs offers a range of in vitro antibody characterization services, including antibody structure analysis, post-translational modifications (PTMs) analysis, antibody aggregation analysis, antibody homogeneity analysis, antibody stability analysis, analytical comparability studies, and antibody forced degradation studies.

  • Engineering and Optimization of Immune Checkpoint Antibody
  • Through modern molecular biology techniques, interested antibodies can be engineered for different purposes. Creative Biolabs has rich experience in the field of antibody engineering, affinity optimization, and antibody stability improvement. We are highly experienced in antibody engineering and optimization of immune checkpoint antibodies. We are confident to provide top-quality service to facilitate therapeutic immune checkpoint antibody development.

  • Production and Manufacture of Immune Checkpoint Antibody
  • A range of expression systems, such as bacteria (Escherichia coli), yeast (Saccharomyces cerevisiae and Pichia pastoris), mammalian cell (CHO, NS0, Sp2/0, HEK 293 and PER.C6), baculoviral insect cell (Sf9, Sf21, and "High Five" cell), plant expression system (Nicotiana benthamiana and N. tabacum) and cell-free systems, are available at Creative Biolabs for the production and manufacture of high-quality mAb antibodies.

Equipped with world-leading technology platforms and professional staff, Creative Biolabs is always dedicated to assisting our clients with the most satisfactory immune checkpoint antibody development service. If you are interested in discovering novel immune checkpoint antibodies, please contact us for more details.

Reference

  1. Gravbrot, N.; et al. Therapeutic monoclonal antibodies targeting immune checkpoints for the treatment of solid tumors. Antibodies. 2019, 8(4):51.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic, or any in vivo human use.