Immune checkpoints are molecules on certain immune cells that need to be activated (or inactivated) to start an immune response. Cancer cells sometimes find ways to use these checkpoints to avoid being attacked by the immune system. However, checkpoint inhibitors that target these checkpoints hold much promise as cancer treatments. For example, monoclonal antibodies that target either programmed cell death 1 (PD-1) or programmed death-ligand 1 (PD-L1) can block this binding and boost the immune response against cancer cells and is shown a great deal of promise in treating certain cancers. By far, more and more immune checkpoint antibodies are being paid increasing attention.
Creative Biolabs has organized a staff of outstanding scientists who have engaged in antibody development for more than ten years. We have the necessary expertise and capabilities to evaluate each immune checkpoint antibody production project individually. Based on our full range of production systems, Creative Biolabs provides rapid production of immune checkpoint antibodies on a small scale or even a large scale as required. Small-scale production is cost-effective for smaller research runs and suitable for early feasibility, clonal selection, and optimization. We can design and customize your project and generate the exact immune checkpoint antibody according to our client's requirements.
Immune Checkpoint Antibody Small-scale Production Services
Custom antibody production at Creative Biolabs can be accomplished by using a wide range of production systems, including bacteria production system, mammalian cells production system, yeast production system, insect cell production system, plant production system, and cell-free production system. Among them, the bacteria expression system and mammalian cells expression system are most wildly used for small-scale antibody production. At Creative Biolabs, your immune checkpoint antibody is in reliable hands. Creative Biolabs provides high-throughput immune checkpoint antibody production and purification services. We offer a portfolio of codon optimization, high-throughput gene synthesis, vector construction, small-scale production, purification, and strict quality control to meet the unique requirements of every client.
Our standard method for immune checkpoint antibody expression of scFv, Fab, or VHH formats is present in Escherichia coli and CHO/HEK 293 cells. Small-scale production can be scaled up for increased yields. scFv, Fab, or VHH can be engineered into a full-length format, including IgG1, IgG2, IgG3, and IgG4, by fusing onto an Fc backbone. Equipped with comprehensive, robust platforms and abundant experience, our experts have acquired significant expertise by producing all kinds of immune checkpoint antibodies.
A wide range of production systems
Low endotoxin levels
Cell line cryo-storage
Reliability and information security
Tailored research & services
With proven experience in immune checkpoint antibody development, Creative Biolabs is an ideal company to entrust with your business. For more detailed information, please feel free to contact us or directly send us an inquiry.
Lee, L.; et al. Immune checkpoint inhibitors: An introduction to the next-generation cancer immunotherapy. The journal of clinical pharmacology. 2016, 56(2):157-69.
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic, or any in vivo human use.