What is Immune Checkpoint

As the field of immunotherapy continues to advance, the importance of immune checkpoints in regulating immune responses has become increasingly clear. These molecular pathways play a critical role in maintaining immune homeostasis, preventing autoimmune diseases, and protecting against cancer. You can explore the complex world of immune checkpoints and the research services that Creative Biolabs offers in this exciting area here.

Introduction to Immune Checkpoints

Immune checkpoints are a set of regulatory pathways that modulate the strength and duration of immune responses. These pathways serve as a brake on the immune system to prevent excessive activation and tissue damage. Immune checkpoints are activated by ligand-receptor interactions, leading to downstream signaling cascades that ultimately inhibit immune cell activity. The dysregulation of immune checkpoints can lead to immune escape, allowing cancer cells to evade immune detection and elimination.

Immune Checkpoint Targets

At Creative Biolabs, we offer a comprehensive list of immune checkpoint targets that have been identified as potential therapeutic targets. These targets include proteins such as PD-1, CTLA-4, TIM-3, and LAG-3, among others. More immune checkpoint molecules can be viewed by clicking here.

Our team of experts is continually evaluating the latest research to identify new checkpoint targets and develop innovative strategies for targeting them.

Immune Checkpoints in Cancer Cells

Understanding the complex interplay between immune checkpoints and cancer cells is critical for developing novel immunotherapies that can effectively target these pathways.

  • In cancer cells, immune checkpoint pathways can be hijacked to promote tumor growth and evade detection by the immune system.
  • By targeting these checkpoint pathways, we can activate the immune response and restore the body's natural ability to identify and destroy abnormal cells.

At Creative Biolabs, we offer a range of research services designed to support this critical work. From structure-based drug design to in vitro assays and in vivo studies, our team of experts is committed to advancing the field of immune checkpoint therapy.

Research Services We Offer

We offer a range of research services focused on immune checkpoints.

  • Our team of experienced scientists has extensive expertise in the development of novel therapeutics targeting these pathways. We offer a comprehensive suite of services, including assay development, target validation, drug discovery, and preclinical testing. Our cutting-edge technologies and state-of-the-art facilities allow us to deliver high-quality, reliable results for our clients.

Immune checkpoints play a critical role in regulating immune responses and maintaining immune homeostasis. Creative Biolabs is committed to advancing this critical work through innovative research services and cutting-edge drug design strategies. Contact us today to learn more about how we can help you advance your research in this exciting area.


  1. Pardoll D M. The blockade of immune checkpoints in cancer immunotherapy. Nature Reviews Cancer, 2012, 12(4), 252-264.
  2. Chen L and Han X. Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. Journal of Clinical Investigation, 2015, 125(9), 3384-3391.
  3. Sharma P and Allison J P. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell, 2015, 161(2), 205-214.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic, or any in vivo human use.