Molecular Imaging for Immune Checkpoint Research

Molecular imaging has proven to be an invaluable tool in biomedical research, enabling non-invasive visualization and quantification of molecular processes in living organisms. Its role in immune checkpoint research is multifaceted and it has emerged as an indispensable tool to unlock the secrets of immune checkpoints.

Creative Biolabs shares resources on molecular imaging of immune checkpoints, as well as offers cutting-edge services and products in this emerging field.

Molecular Imaging for Targeting Immune Checkpoints

Understanding the spatial and temporal dynamics of immune checkpoint expression in the tumor microenvironment is critical for developing and optimizing immunotherapy strategies. This is where molecular imaging of immune checkpoints comes into play.

  • Real-time visualization of immune checkpoint dynamics

Molecular imaging techniques such as positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) have enabled researchers to track the spatiotemporal dynamics of immune checkpoint molecules. This real-time visualization provides unprecedented insights into the behavior of immune checkpoint receptors and their ligands during immune responses and disease progression.

  • Detecting immune checkpoint expression and distribution

Molecular imaging employs innovative imaging probes specifically targeting immune checkpoint molecules, enabling researchers to detect and quantify their expression levels in healthy and pathological tissues. This capability is critical for understanding the spatial distribution and abundance of immune checkpoints in the tumor microenvironment and the immune cells that infiltrate the tumor.

  • Assessing immune checkpoint inhibitor efficacy

By employing molecular imaging, researchers can assess the efficacy of immune checkpoint inhibitors in real time and monitor changes in immune checkpoint expression following treatment.

Challenges and Promises

Many advanced imaging modalities including PET, SPECT and MRI are optimized for immune checkpoint studies. These modalities provide unparalleled sensitivity and spatial resolution, facilitating precise imaging of immune checkpoint molecules in various tissues and immune cell populations. While molecular imaging has great potential to advance immune checkpoint research, it also faces many challenges. In the face of challenges, Creative Biolabs offers a range of services in the field of molecular imaging of immune checkpoints based on its multidisciplinary expertise and relentless pursuit of scientific excellence.

  • Highly selective imaging probes: To meet the need for target specificity, we can design a broad portfolio of highly selective imaging probes. These probes are designed to specifically bind immune checkpoint molecules and ligands, ensuring accurate and reliable imaging data without off-target effects.
  • Cutting-edge radiolabeling technologies: To maximize the sensitivity and resolution of imaging probes, cutting-edge radiolabeling technologies can be developed. These technologies enable efficient and stable integration of radioisotopes into imaging probes to facilitate precise tracking and quantification of immune checkpoint dynamics.

Advances in Immune Checkpoint Molecular Imaging

Looking ahead, the combination of immune checkpoint research and molecular imaging is promising.

  • Novel imaging probes and modalities

Ongoing research and development efforts are expected to result in a broader range of imaging probes and modalities, expanding the arsenal of tools available to immune checkpoint study researchers. These advances will enhance the depth and breadth of molecular insights into immune checkpoint biology.

  • Artificial intelligence integration

Integrating artificial intelligence and machine learning algorithms into molecular imaging data analysis has the potential to accelerate data interpretation and reveal complex patterns and correlations that may have been overlooked. This approach can accelerate the translation of molecular imaging findings into actionable clinical decisions.

Creative Biolabs' unwavering commitment to scientific innovation has played a key role in advancing molecular imaging of immune checkpoints. Through pioneering efforts in developing cutting-edge imaging technologies and probes, we hope to push the boundaries of what is possible.


  1. GAO Y, et al. PET/CT molecular imaging in the era of immune-checkpoint inhibitors therapy. Front Immunol, 2022, 13: 1049043.
  2. WESTDORP H, et al. Toward a better understanding of immune checkpoint inhibitor radiolabeled PET imaging studies. J Nucl Med, 2022, 63(3): 359-361.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic, or any in vivo human use.